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First factor the each term in the expression.

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100x3 2 · 2 · 5 · 5 · x · x · x

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75y3 3 · 5 · 5 · y · y · y

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The GCF is the product of the common prime factors in each term.

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GCF = 5 · 5 = 25\"\"

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The greatest common factor of 100x3 and 75y3 is 25.